PICK
New Orleans Pelicans +3.5 -108

Indiana Pacers vs New Orleans Pelicans Prediction, Odds, Best Bets - Opening Week

Zion Williamson
Zion Williamson. Photo: Erik Drost, CC BY 2.0, via Wikimedia Commons
INDIANA PACERS0-0
VS
NEW ORLEANS PELICANS0-0
SPREAD
Indiana Pacers -3.5
TOTAL
241.5
MONEYLINE
Indiana Pacers -162
Wednesday, October 21, 2026 · 7:00 PM CT · League PassSmoothie King Centerodds updated today

Indiana Pacers opens at New Orleans Pelicans on Wednesday. Last season: Indiana Pacers 19-63 (-8.0/game), New Orleans Pelicans 26-56 (-4.5/game). Our data-driven pick: New Orleans Pelicans +3.5.

01The Matchup

Indiana Pacers opens the season at New Orleans Pelicans on Wednesday night at Smoothie King Center, and the starting point is what these teams were the last time basketball counted. New Orleans Pelicans finished last season 26-56, scoring 115.5 points per game and allowing 120.0 for a -4.5 differential. Indiana Pacers came in at 19-63 with 112.4 scored and 120.4 allowed per game, a -8.0 differential.

Openers are noisy, which is exactly why the baseline matters: rosters turn over at the margins, but the cores that produced those numbers are intact, led by Tyrese Haliburton for Pacers and Zion Williamson for Pelicans. The market opens Indiana Pacers -3.5 with a total of 241.5, a number that respects New Orleans Pelicans after a 26-56 campaign, and opening night at Smoothie King Center gives the home crowd its usual say before the basketball settles anything.

02Key Factors

First, the efficiency gap is the game. New Orleans Pelicans were outscored by 4.5 points per game last season while Indiana Pacers sat at -8.0, and even after regressing both marks halfway toward zero for a new season, the projection still lands on New Orleans Pelicans by a real margin.

Second, the scoring environment cuts toward the under: these teams combined to average 227.9 points scored and 240.4 allowed per game last season, which projects near 94.0 against a posted total of 241.5. Pace and shot quality on opening night rarely match midseason form, so the team that defends without fouling early sets the terms.

Third, the star minutes matter more in game one than game forty. Zion Williamson and Tyrese Haliburton will both play heavy minutes with fresh legs, rotations are at their shortest and most talented, and that compresses the bench minutes where underdogs usually steal runs. If Zion Williamson gets his normal diet of shots, the talent math from last season has room to show up in full.

03The Pick

Take New Orleans Pelicans +3.5 at -108. Regressing last season's differentials halfway and adding 2.2 points for home court projects New Orleans Pelicans by +4.0 in this spot, against a market margin of -3.5, which leaves the value on New Orleans Pelicans. The case is not one number: New Orleans Pelicans brings the stronger baseline (26-56, -4.5 per game last season), the best player on the floor in Zion Williamson, and a supporting scorer in Trey Murphy III who keeps the offense functional when the first option sits.

Opening night cuts both ways and the honest caveat is real - one hot shooting quarter from Tyrese Haliburton flips any spread this small - but at a near pick'em price band the side with the better full-season profile and the cleaner projection is the side to back. New Orleans Pelicans +3.5.

OUR VERDICT
New Orleans Pelicans +3.5 -108

Regressed last-season differential model projects New Orleans Pelicans +4.0 vs a market margin of -3.5; New Orleans Pelicans carried a -4.5 per-game differential last season.

One more game on the board: our thoughts on who covers in Chicago Bulls vs Toronto Raptors.

Every pick is published with its line before the game. Odds via consensus sportsbooks at time of writing and move constantly. Must be 21+. If gambling is a problem, call or text 1-800-GAMBLER.